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Merck
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資料

安全性情報

C223

Sigma-Aldrich

Cirazoline hydrochloride

solid

別名:

2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride

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About This Item

実験式（ヒル表記法）:
C13H16N2O · HCl
CAS番号:
40600-13-3
分子量:
252.74
EC Number:
254-995-3
MDL番号:
MFCD00274034
UNSPSCコード:
12352200
PubChem Substance ID:
24277770
NACRES:
NA.77

形状

solid

色

white

溶解性

H2O: >35 mg/mL

SMILES記法

Cl[H].C1CN=C(COc2ccccc2C3CC3)N1

InChI

1S/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13;/h1-4,10H,5-9H2,(H,14,15);1H

InChI Key

XFRXWLWUUDJHPB-UHFFFAOYSA-N

遺伝子情報

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

アプリケーション

Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.

生物化学的／生理学的作用

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.

特徴および利点

This compound is featured on the α1-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

C223-VAR:
C223-10MG:
C223-25MG:
C223-BULK:

試験成績書（COA）

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以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Bronwyn A Evans et al.
Molecular pharmacology, 79(2), 298-307 (2010-10-28)
Although G protein-coupled receptors are often categorized in terms of their primary coupling to a given type of Gα protein subunit, it is now well established that many show promiscuous coupling and activate multiple signaling pathways. Furthermore, some agonists selectively
Aarthi Kamath et al.
The international journal of neuropsychopharmacology, 11(8), 1085-1096 (2008-05-08)
Neonatal ventral hippocampus (nVH) lesion in rats is a widely used animal model of schizophrenia due to the predominantly post-pubertal emergence of many schizophrenia-like behaviours. Our previous studies have shown increased ligand binding of alpha1 adrenergic receptors (AR) in the
Jinhwan Kim et al.
Molecules (Basel, Switzerland), 24(4) (2019-02-24)
Although melanin production is a key self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage, uneven or excessive deposition of melanin causes hyperpigmentary disorders. Currently available whitening agents are unsatisfactory because of issues with efficacy and safety. To develop more effective
Karen M Alsene et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 31(10), 2150-2161 (2006-01-13)
Prepulse inhibition (PPI) refers to the attenuation of startle when a weak prestimulus precedes the startling stimulus. PPI is deficient in several psychiatric illnesses involving poor sensorimotor gating. Previous studies indicate that alpha1 adrenergic receptors regulate PPI, yet the extent
Vito Bellantuono et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 148(2), 160-164 (2008-06-12)
Frog skin transports ions and water under hormonal control. In spite of the fundamental role played by adrenergic stimulation in maintaining the water balance of the organism, the receptor subtype(s) present in the skin have not been identified yet. We
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資料

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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