C1240
Chlormethiazole hydrochloride
≥98% (HPLC), powder
別名:
4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride
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すべての画像(1)
About This Item
実験式（ヒル表記法）:
C6H8ClNS · HCl
CAS番号:
分子量:
198.11
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77
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詳細
Store desiccated
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
off-white
溶解性
H2O: soluble >10 mg/mL
オーガナイザー
AstraZeneca
SMILES記法
Cl.Cc1ncsc1CCCl
InChI
1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
InChI Key
OFXYKSLKNMTBHK-UHFFFAOYSA-N
生物化学的／生理学的作用
Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
GABAA agonist; glycine receptor modulator.
特徴および利点
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C1240-50MG:
C1240-VAR:
C1240-BULK:
C1240-10MG:
A Nurse's Survival Guide to Acute Medical Emergencies (2011)
Koichi Nisijima et al.
Neurochemistry international, 43(2), 155-164 (2003-03-07)
The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg)
Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)
Rachael M Nelson et al.
European journal of pharmacology, 452(3), 255-262 (2002-10-03)
Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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