C0913

補体C2欠損血清 ヒト

for complement assays

• CAS番号: 80295-40-5
• MDL番号: MFCD00130835
• UNSPSCコード: 12352202
• NACRES: NA.61

特性

• 由来生物: human
• 品質水準: 200
• フォーム: liquid
• テクニック: activity assay: suitable
• UniProtアクセッション番号: P06681
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... C2(717)

詳細

アプリケーション

C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing.

生物化学的／生理学的作用

Heritable complement C2 deficiency can manifest as a number of severe dermatological disorders, including discoid lupus erythematosus, idiopathic atrophoderma, and dermatomyositis.

物理的形状

PBS(pH 7.2)溶液。

アナリシスノート

C2が免疫吸着により除去されていることを高感度溶血アッセイやオクタロニ-免疫拡散法で確認済

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable