B5188

塩酸ブテナフィン

≥98% (HPLC)

• 別名: ブテナフィン 塩酸塩, N-(p-tert-ブチルベンジル)-N-メチル-1-ナフタレンメチルアミン 塩酸塩, N-[[4-(1,1-ジメチルエチル)フェニル]メチル]-N-メチル-1-ナフタレンメタンアミン 塩酸塩, メンタックス
• 実験式（ヒル表記法）: C₂₃H₂₇N · HCl
• CAS番号: 101827-46-7
• 分子量: 353.93
• MDL番号: MFCD00917064
• UNSPSCコード: 51111800
• PubChem Substance ID: 329773252
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to off-white
• 溶解性: DMSO: ≥10 mg/mL
• オーガナイザー: Schering Plough
• 保管温度: room temp
• SMILES記法: Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23
• InChI: 1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
• InChI Key: LJBSAUIFGPSHCN-UHFFFAOYSA-N

詳細

詳細

Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.

アプリケーション

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.

生物化学的／生理学的作用

Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.

Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.

特徴および利点

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H312
• 注意書き: P280 - P302 + P352 + P312 - P362 + P364 - P501
• 危険有害性の分類: Acute Tox. 4 Dermal
• 保管分類コード: 11 - Combustible Solids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable