製品名
骨形成タンパク質2 ヒト, Carrier Free, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
≥98% (SDS-PAGE)
フォーム
lyophilized powder
分子量
26 kDa
包装
pkg of 10 μg
保管条件
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
テクニック
cell culture | mammalian: suitable
不純物
Endotoxin, tested
色
white
溶解性
water: soluble 0.100 mL, clear, colorless
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... BMP2(650)
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生物化学的／生理学的作用
Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.
物理的形状
Lyophilized from a 0.2 μm filtered buffered solution.
アナリシスノート
The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
104.0 °F - closed cup
引火点(℃)
40.0 °C - closed cup
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
B1814-VAR:
B1814-10UG:
B1814-BULK:
B1814-10UG-PW:
Ernst B Hunziker et al.
Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)
The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the
Fengxuan Han et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(7), 1344-1353 (2014-11-12)
Repair of cartilage-bone interface tissue remains challenging, because it combines different cell types and gradients of composition and properties. To enable simultaneous regeneration of bone, cartilage, and especially their interface, a conically graded scaffold of chitosan-gelatin hydrogel/poly(l-lactide-co-glycolide) (PLGA) was facilely
Lindsay A Bonsignore et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(7), 979-987 (2015-02-14)
The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration leads to a direct structural and functional connection between living bone and the surface of an implant. Surface contaminants may remain on
Thorsten Pfirrmann et al.
Human molecular genetics, 24(11), 3119-3132 (2015-02-26)
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
Liping Wang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1212-1217 (2015-03-17)
Available evidence indicates that some Tie2-expressing (Tie2(+) ) cells serve as multipotent progenitors that have robust BMP-dependent osteogenic activity and mediate heterotopic ossification (HO). Since signaling through the G protein Gi is required for cell motility, we hypothesized that blockade
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