おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
52 kDa
交差性
mouse, guinea pig, horse, dog, human, bovine, rat, rabbit
濃度
0.5 mg - 1 mg/mL
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... SHC1(6464)
免疫原
Synthetic peptide directed towards the C terminal region of human SHC1
アプリケーション
Anti-SHC1 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.
生物化学的／生理学的作用
Src homology 2 domain containing) transforming protein 1 (SHC1; SHC; SHCA) gene encodes three isoforms, p66Shc, p52Shc and p46Shc. p52Shc and p46Shc are involved recruitment of Grb2/Sos complex and activation of Ras pathway. p66Shc is involved in regulating the effects of reactive oxygen species and aging.
シーケンス
Synthetic peptide located within the following region: AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
物理的形状
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AV50490-50UG:
AV50490-100UL:
最新バージョンのいずれかを選択してください：
Alessandra Berry et al.
Neuroscience and biobehavioral reviews, 37(5), 790-802 (2013-03-26)
Life expectancy in the last century has greatly increased although, in most industrialized countries, this has been paralleled by an increased incidence of neurodegenerative disorders, in addition to cardiovascular and metabolic pathologies. The p66(Shc) gene has emerged as a novel
Elena De Marchi et al.
Oxidative medicine and cellular longevity, 2013, 564961-564961 (2013-04-23)
Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and
K S Ravichandran
Oncogene, 20(44), 6322-6330 (2001-10-19)
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then a number of studies in multiple systems have implicated a role for Shc in signaling via many different types of receptors
Santosh Kumar et al.
Biochemical and biophysical research communications, 449(4), 496-501 (2014-05-23)
Hypercholesterolemia leads to a prothrombotic phenotype. Platelet hyperactivity associated with hypercholesterolemia has been attributed, in part, to oxidative stress. P66Shc is a well-known determinant of cellular and organismal oxidative stress. However, its role in platelet biology is not known. We
M Halon et al.
Free radical research, 48(11), 1363-1370 (2014-09-02)
Recently, iron and the adaptor protein "p66Shc" have been shown to play an important role in the development of amyotrophic lateral sclerosis (ALS) in rats. We hypothesized that changes in muscle p66Shc activity and iron metabolism would appear before visible
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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