59983

ジョサマイシン

≥90% (HPLC)

• 別名: Leucomycin A3
• 実験式（ヒル表記法）: C₄₂H₆₉NO₁₅
• CAS番号: 16846-24-5
• 分子量: 827.99
• EC Number: 240-871-6
• MDL番号: MFCD00211043
• UNSPSCコード: 51101500
• PubChem Substance ID: 57651709
• NACRES: NA.85

特性

• 品質水準: 200
• アッセイ: ≥90% (HPLC)
• 形状: powder
• 色: white to slightly yellow
• 抗生物質活性スペクトル: Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
• InChI: 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
• InChI Key: XJSFLOJWULLJQS-NGVXBBESSA-N

詳細

詳細

Chemical structure: macrolide

アプリケーション

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

生物化学的／生理学的作用

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

包装

底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。

その他情報

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)