50239

Gly-Gly-Gly

≥99.0% (NT), suitable for ligand binding assays, BioUltra

• 別名: グリシル-グリシル-グリシン, トリグリシン
• 化学式: NH₂CH₂CONHCH₂CONHCH₂COOH
• CAS番号: 556-33-2
• 分子量: 189.17
• Beilstein: 1711130
• EC Number: 209-122-0
• MDL番号: MFCD00036223
• UNSPSCコード: 12352209
• PubChem Substance ID: 57651245
• NACRES: NA.26

特性

• 製品名: Gly-Gly-Gly, BioUltra, ≥99.0% (NT)
• 製品種目: BioUltra
• 品質水準: 100
• アッセイ: ≥99.0% (NT)
• フォーム: powder
• テクニック: ligand binding assay: suitable
• 不純物: insoluble matter, passes filter test
• 強熱残分: ≤0.1% (as SO₄)
• 損失: ≤0.5% loss on drying, 110 °C
• 色: white
• pH: 4.5-6.0 (25 °C, 0.5 M in H₂O)
• 溶解性: H₂O: 0.5 M at 20 °C, clear, colorless
• 微量陰イオン: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• 微量陽イオン: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤50 mg/kg; Bi: ≤5 mg/kg; Ca: ≤20 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 0.5 M in H₂O
• UV吸収: λ: 260 nm A_max: 0.15; λ: 280 nm A_max: 0.10
• SMILES記法: NCC(=O)NCC(=O)NCC(O)=O
• InChI: 1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)
• InChI Key: XKUKSGPZAADMRA-UHFFFAOYSA-N

詳細

Amino Acid Sequence

Gly-Gly-Gly

詳細

Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

アプリケーション

<ul>
<li><strong>Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy:</strong> Research explores Gly-Gly-Gly peptides as potential enhancers for drug transport efficiency, positioning them as valuable tools in clinical diagnostic peptide development for targeted cancer therapies (Gong et al., 2017).</li>
<li><strong>Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains:</strong> This study demonstrates the use of Gly-Gly-Gly in the synthesis of complex metal-peptide frameworks for potential use in high-purity peptide applications in IVD manufacturing (&Aacute;lvarez et al., 2012).</li>
</ul>

生物化学的／生理学的作用

ビューレット反応による再現性のある血清タンパク質測定とアミノトリぺプチダーゼのアッセイに使用される基質。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)