おすすめの製品
由来生物
mouse
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
MRQ-44, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
フォーム
buffered aqueous solution
交差性
human
包装
vial of 0.1 mL concentrate (367M-14)
vial of 0.5 mL concentrate (367M-15)
bottle of 1.0 mL predilute (367M-17)
vial of 1.0 mL concentrate (367M-16)
bottle of 7.0 mL predilute (367M-18)
メーカー／製品名
Cell Marque®
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
アイソタイプ
IgG1κ
コントロール
tonsil
輸送温度
wet ice
保管温度
2-8°C
視覚化
cytoplasmic
詳細
The igG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues.
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
IgG4 Positive Control Slides, Product No. 367S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法的情報
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
Lot/Batch Number
Sudhir Dhobale et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 15(7), 354-357 (2009-12-17)
Great attention has been drawn toward the recently defined IgG4 related sclerosing disease, an entity incorporating autoimmune pancreatitis and other organ involvements, hypergammaglobulinemia and deposition of IgG4 in affected tissues. We demonstrate an index case of this disease with multiple
Noriyuki Sakata et al.
The American journal of surgical pathology, 32(4), 553-559 (2008-02-28)
Inflammatory abdominal aortic aneurysm (IAA) is associated with autoimmune disease. However, the precise mechanism of IAA remains unclear. There is increasing evidence that IgG4 is involved in the autoimmune mechanism of various idiopathic sclerosing lesions, including sclerosing pancreatitis and retroperitoneal
Yasuharu Sato et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(4), 589-599 (2009-03-10)
IgG4-related disease sometimes involves regional and/or systemic lymph nodes, and often clinically and/or histologically mimics multicentric Castleman's disease or malignant lymphoma. In this study, we examined clinical and pathologic findings of nine patients with systemic IgG4-related lymphadenopathy. None of these
Masanori Koyabu et al.
Journal of gastroenterology, 45(7), 732-741 (2010-01-21)
Patients with autoimmune pancreatitis (AIP) characteristically show elevated serum levels of immunoglobulin G4 (IgG4) and abundant infiltration of IgG4-positive plasmacytes in the involved organs. The most common involved organ showing extrapancreatic lesions is the bile duct, which exhibits sclerosing cholangitis
Vikram Deshpande et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(10), 1287-1295 (2009-07-28)
IgG4-associated cholangitis is a steroid-responsive hepatobiliary inflammatory condition associated with autoimmune pancreatitis that clinically and radiologically mimics primary sclerosing cholangitis. In this study, we conducted a morphological and immunohistochemical analysis of liver material obtained from individuals with IgG4-associated cholangitis, and
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