321R-2

PLAP (EP194) Rabbit Monoclonal Primary Antibody

• 別名: Placental Alkaline Phosphatase
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: EP194, monoclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 包装: vial of 0.1 mL concentrate (321R-24); vial of 0.1 mL concentrate Research Use Only (321R-24-RUO); vial of 0.5 mL concentrate (321R-25); vial of 1.0 mL concentrate (321R-26); vial of 1.0 mL concentrate Research Use Only (321R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (321R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (321R-27); vial of 7.0 mL pre-dilute ready-to-use (321R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (321R-28-RUO)
• メーカー／製品名: Cell Marque^™
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• アイソタイプ: IgG
• コントロール: placenta
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: cytoplasmic
• 遺伝子情報: human ... ALPP(250)

詳細

詳細

Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and syncytiotrophoblasts, and the detection of its expression has been useful in identifying germ cell tumors. Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. Complete hydatidiform mole shows strong expression of hCG and weak expression of PLAP. Weak hCG and strong PLAP expression is found in partial hydatidiform mole. Choriocarcinoma presents strong expression of hCG and weak expression of hPL and PLAP.8 In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in identifying soft tissue tumors.

品質

IVD

IVD

IVD

RUO

関連事項

PLAP Positive Control Slides, Product No. 321S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

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その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable