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Merck

284M-9

Sigma-Aldrich

Microphthalmia Transcription Factor (MiTF) (C5/D5) Mouse Monoclonal Antibody

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

mouse

品質水準

100
500

結合体

unconjugated

抗体製品の状態

culture supernatant

抗体製品タイプ

primary antibodies

クローン

C5/D5, monoclonal

詳細

For In Vitro Diagnostic Use in Select Regions (See Chart)

フォーム

buffered aqueous solution

交差性

human

包装

vial of 0.1 mL concentrate (284M-94)
vial of 0.5 mL concentrate (284M-95)
bottle of 1.0 mL predilute (284M-97)
vial of 1.0 mL concentrate (284M-96)
bottle of 7.0 mL predilute (284M-98)

メーカー/製品名

Cell Marque®

テクニック

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

アイソタイプ

IgG1

コントロール

melanoma

輸送温度

wet ice

保管温度

2-8°C

視覚化

nuclear

遺伝子情報

human ... MITF(4286)

詳細

Mi is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).

品質


IVD

IVD

IVD

RUO

関連事項

Microphthalmia Transcription Factor (MiTF) Positive Control Slides, Product No. 284S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Bernadette Liegl et al.
The American journal of surgical pathology, 32(4), 608-614 (2008-02-19)
PEComas arising in somatic soft tissue or skin are rare. To further characterize the clinicopathologic spectrum, we herein report a series of 10 primary cutaneous PEComas. Eight patients were female and 2 patients were male. The age at presentation ranged
Ilan Weinreb et al.
Virchows Archiv : an international journal of pathology, 450(4), 463-470 (2007-03-23)
Four cases of malignant PEComas were stained with smooth muscle actin, muscle specific actin, desmin, human melanoma black-45, melan-A, microphthalmia transcription factor, S100 and cyclin D1. One case was studied by electron microscopy (EM). Tumour locations were the thigh, elbow
Alberto Righi et al.
International journal of surgical pathology, 16(1), 16-20 (2008-01-22)
We report 2 cases of PEComa, one occurring in the colon of an 11-year-old boy and the other in the bone (fibula) of a 92-year-old woman. Both tumors consisted of nests of large epithelioid cells surrounded by a fibrovascular stroma.
Jason L Hornick et al.
The American journal of surgical pathology, 32(4), 493-501 (2008-01-29)
PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin. We
Steven J Ohsie et al.
Journal of cutaneous pathology, 35(5), 433-444 (2008-04-11)
Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas from these other tumors; it has also been studied for use as an adjunct to

資料

Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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