228M-1

BG8, Lewis^Y (F3) Mouse Monoclonal Antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: F3, monoclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions (See Chart)
• フォーム: buffered aqueous solution
• 交差性: human
• 包装: vial of 0.1 mL concentrate (228M-14); vial of 0.5 mL concentrate (228M-15); bottle of 1.0 mL predilute (228M-17); vial of 1.0 mL concentrate (228M-16); bottle of 7.0 mL predilute (228M-18)
• メーカー／製品名: Cell Marque^®
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• アイソタイプ: IgM
• コントロール: adenocarcinoma of lung
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: cytoplasmic
• 遺伝子情報: human ... F3(2152)

詳細

詳細

Blood group antigens have been examined as potential discriminators between pulmonary adenocarcinoma (PACA) and epithelioid mesothelioma (EM). Lewis^y is the only one of these that appears to have some merit. BG8 is raised from the SK-LU-3 lung cancer line and its ability to distinguish between PACA and EM was first reported by Jordon and colleagues in 1989. Three groups have since reported their results. These studies included 231 cases of PACA and 197 cases of EM. Sensitivity and specificity for PACA were both 93%. Yaziji H et al. reported a sensitivity of nonmesothelial antigens for adenocarcinoma as organ dependent, with BG8 performing at 98% in the breast cancer group, and 100% in the lung cancer group. The specificity of the nonmesothelial (non-EM) antigens for adenocarcinoma was 98% for BG8. They concluded using logical regression analysis that a three-antibody immunohistochemical panel including calretinin, BG8, and MOC-31 would provide 96% sensitivity and specificity for distinguishing EM from adenocarcinoma from a variety of sources (lung, ovary, breast, stomach).

品質

IVD

IVD

IVD

RUO

関連事項

BG8 Positive Control Slides, Product No. 228S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany