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由来生物
synthetic
グレード
pharmaceutical primary standard
認証
EP
APIファミリー
diacerein
フォーム
solid
メーカー／製品名
EDQM
テクニック
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
アプリケーション
pharmaceutical (small molecule)
フォーマット
neat
保管温度
2-8°C
SMILES記法
OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
InChI
1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
InChI Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
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詳細
Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
アプリケーション
Diacerein impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生物化学的／生理学的作用
緩下剤/瀉下薬; 内生のアセチルコリンを放出し、腸の平滑筋の収縮を増加させます。抗腫瘍活性は、ミトコンドリアの膜電位を減少させ、最終的には細胞のアポト-シスにつながる一連の事象を作動させる膜透過性転移を引き起こす、活性酸素種(ROS)産生の増加に結びつきます。生殖毒性と変異誘発性はアロエエモジンによるトポイソメラ-ゼ II活性の抑制のためであるようです。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
その他情報
Sales restrictions may apply.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
A solid-liquid extraction and high performance thin layer chromatographic determination of diacerein and aceclofenac in pharmaceutical tablet dosage form
Bhalerao S, et al.
Asian Journal of Pharmaceutical and Clinical Research, 3(1), 25-30 (2010)
Chaudhari Ashok et al.
Journal of pharmaceutical and biomedical analysis, 49(2), 525-528 (2009-01-10)
Two impurities were found in the crude sample of diacerein. The level of these impurities 1.14% and 1.24% were detected by isocratic reverse-phase high performance liquid chromatography (HPLC). The molecular weights of the impurities were determined by liquid chromatography-mass spectroscopy
Naraganahalli R Thimmegowda et al.
Chemical biology & drug design, 85(5), 638-644 (2014-10-18)
In this study, we have synthesized novel water soluble derivatives of natural compound aloe emodin 4(a-j) by coupling with various amino acid esters and substituted aromatic amines, in an attempt to improve the anticancer activity and to explore the structure-activity
Khalilah Haris et al.
Asian Pacific journal of cancer prevention : APJCP, 15(11), 4499-4505 (2014-06-28)
Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant to various chemotherapeutic agents. Hence, approaches have been intensively investigated to targeti specific molecular pathways involved in glioblastoma development and progression. Aloe emodin is believed to modulate
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