SMB00975

Bisdesethylchloroquine Hydrochloride

• 別名: Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
• 実験式（ヒル表記法）: C₁₄H₁₈ClN₃ · xHCl
• 分子量: 263.77 (free base basis)
• MDL番号: MFCD00871854
• UNSPSCコード: 41116105
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 200
• フォーム: solid
• 保管温度: 2-8°C
• SMILES記法: Clc1cc2nccc(c2cc1)NC(CCCN)C
• InChI: 1S/C14H18ClN3/c1-10(3-2-7-16)18-13-6-8-17-14-9-11(15)4-5-12(13)14/h4-6,8-10H,2-3,7,16H2,1H3,(H,17,18)
• InChI Key: GYEDIFVVTRKXHP-UHFFFAOYSA-N

詳細

詳細

Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.

アプリケーション

Metabolomics research

その他情報

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安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable