SMB00963

Desethylchloroquine

≥95% (HPLC)

• 別名: 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline, 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline, N-Desethyl chloroquine, N-Desethylchloroquine, N⁴-(7-Chloro-4-quinolinyl)-N¹-ethyl-1,4-pentanediamine, Monodeethylchloroquine, Monodesethylchloroqu​ine
• 実験式（ヒル表記法）: C₁₆H₂₂ClN₃
• CAS番号: 1476-52-4
• 分子量: 291.82
• MDL番号: MFCD00871808
• UNSPSCコード: 41116107
• NACRES: NA.77

特性

• 由来生物: synthetic
• 品質水準: 200
• グレード: research grade
• アッセイ: ≥95% (HPLC)
• フォーム: powder or crystals
• テクニック: HPLC: suitable
• 色: white to off-white
• 輸送温度: wet ice
• 保管温度: 2-8°C
• SMILES記法: ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2
• InChI: 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
• InChI Key: MCYUUUTUAAGOOT-UHFFFAOYSA-N

詳細

詳細

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.

アプリケーション

Application: Metabolomics research

その他情報

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安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable