PHR1292

ジドブジン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 3′-アジド-3′-デオキシチミジン, AZT, ZDV, アジドチミジン, ジドブジン
• 実験式（ヒル表記法）: C₁₀H₁₃N₅O₄
• CAS番号: 30516-87-1
• 分子量: 267.24
• Beilstein: 3595791
• MDL番号: MFCD00006536
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823283
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 803; traceable to Ph. Eur. Z1900000; traceable to USP 1724500
• APIファミリー: zidovudine
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 113-115 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
• InChI Key: HBOMLICNUCNMMY-XLPZGREQSA-N

詳細

詳細

Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV. The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

アプリケーション

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography and spectrophotometric techniques.

生物化学的／生理学的作用

HIV-1ウイルスに対して活性を示す逆転写酵素インヒビタ-です。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H341,H351
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Carc. 2 - Muta. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable