12805

(ベンゾトリアゾール-1-イルオキシ)トリピロリジノホスホニウムヘキサフルオロホスファート

≥97.0% (TLC), for peptide synthesis

• 別名: PyBOP^®
• 化学式: C₁₈H₂₈N₆OP · PF₆
• CAS番号: 128625-52-5
• 分子量: 520.39
• Beilstein: 3584612
• MDL番号: MFCD00077411
• UNSPSCコード: 12352101
• PubChem Substance ID: 329749882
• NACRES: NA.22

特性

• 製品名: (ベンゾトリアゾール-1-イルオキシ)トリピロリジノホスホニウムヘキサフルオロホスファート, purum, ≥97.0% (TLC)
• グレード: purum
• 品質水準: 200
• アッセイ: ≥97.0% (TLC)
• フォーム: solid
• 反応適合性: reaction type: Coupling Reactions
• mp: ~150 °C; 154-156 °C (dec.) (lit.)
• アプリケーション: peptide synthesis
• 保管温度: 2-8°C
• SMILES記法: F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
• InChI: 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
• InChI Key: VIAFLMPQBHAMLI-UHFFFAOYSA-N

詳細

詳細

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

アプリケーション

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:

• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

副生成物として発がん性のHMPAを生成しないBOPカップリング試薬の類縁体。

法的情報

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H317,H410
• 注意書き: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves