SCC255

WT-1 Mouse Brown Preadipocyte Cell Line

WT-1 mouse brown preadipocyte cell line is a useful model for studying adipogenesis and brown adipocyte biology.

• 別名: Brown Preadipocyte Cells, Mouse Brown Preadipocytes, WT-1 Preadipocyte Cells
• UNSPSCコード: 41106514
• NACRES: NA.81

特性

• テクニック: cell differentiation: suitable

詳細

詳細

Obesity is a growing worldwide health epidemic that has spurred research into new avenues for treatment and control of metabolic disorders. Brown fat, a specialized adipose tissue characterized by increased energy expenditure, has emerged as an area of interest because manipulation of this tissue has potential to protect against diet-induced obesity by altering the balance of energy intake and consumption (1).

The WT-1 mouse immortalized brown preadipocyte cell line is derived from primary brown preadipocytes. WT-1 preadipocytes can be induced to differentiate into brown adipocytes upon treatment with induction and differentiation factors. WT-1 cells express the brown fat differentiation factor BMP7 and brown fat marker uncoupling protein-1 (UCP1) (3) and are a valuable model for investigation into mitochondrial physiology during adipogenesis. The WT-1 cell line has been used to develop 3D assays for adipose tissue (4) and is well suited for a range of questions in cellular metabolic research.

<bold>Source:</bold>
WT-1 cell line was established from primary brown pre-adipocytes isolated from newborn mouse pups and immortalized with Simian virus 40 (SV40) large T antigen (2).

Research Category:
Stem Cell Research

細胞株の由来

Mouse, Adipocytes

包装

&ge;1X10⁶ cells/vial

保管および安定性

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

その他情報

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

免責事項

This product contains genetically modified organisms (GMO).
Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable