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Key Documents

安全性情報

MABT861M

Sigma-Aldrich

Anti-CDCP1 (CD318) Antibody, clone 9A2

clone 9A2, from mouse

別名:

CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318

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About This Item

UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41

由来生物

mouse

品質水準

抗体製品の状態

purified immunoglobulin

抗体製品タイプ

primary antibodies

クローン

9A2, monoclonal

化学種の反応性

mouse, human

包装

antibody small pack of 25 μg

テクニック

flow cytometry: suitable

アイソタイプ

IgG2bκ

NCBIアクセッション番号

UniProtアクセッション番号

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... CDCP1(64866)

関連するカテゴリー

詳細

CUB domain-containing protein 1 (UniProt: Q9H5V8; also known as Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318) is encoded by the CDCP1 (also known as TRASK) gene (Gene ID: 64866) in human. CUB domain-containing protein 1 is a single-pass membrane protein that is synthesized with a 29 amino acid signal peptide, which is subsequently cleaved to generate the mature form. A soluble form of CUB domain-containing protein 1 has also been reported that is produced by proteolytic cleavage at the cell surface. CUB domain-containing protein 1 is highly expressed in mitotic cells with low expression during interphase. It is detected at highest levels in skeletal muscle and colon. Lower expression is reported in kidney, small intestine, placenta, and lung. It is also reported in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. CUB domain-containing protein 1 levels are up-regulated in a number of human tumor cell lines and in colorectal cancer, breast carcinoma and lung cancer. It is reported to be involved in cell adhesion and cell matrix association and may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation.

特異性

Clone 9A2 detects CUB domain-containing protein 1 in human and murine cells. It targets an epitope within the extracellular domain.

免疫原

Epitope: extracellular domain
His-tagged recombinant fragment corresponding to 638 amino acids from the internal region of human CUB domain-containing protein 1.

アプリケーション

Research Category
細胞骨格
Anti-CDCP1 (CD318), clone 9A2, Cat. No. MABT861, is a mouse monoclonal that detects CUB domain-containing protein 1 and has been tested for use in Flow Cytometry.
Flow Cytometry Analysis: 1 µg from a representative lot detected CDCP1 CD318 in MDA-MB231 cells.


品質

Evaluated by Flow Cytometry in DLD-1 cells.

Flow Cytometry Analysis: 1 µg of this antibody detected CDCP1 CD318 in one million DLD-1 cells.

ターゲットの説明

92.93 kDa calculated.

物理的形状

Protein G purified
Format: Purified
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

12 - Non Combustible Liquids

WGK

WGK 1


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

MABT861:
MABT861-25UG:


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