MABN124

Anti-ATF-3 Antibody, clone 13A5.1

clone 13A5.1, from human(Recombinant)

• 別名: Cyclic AMP-dependent transcription factor ATF-3, Activating transcription factor 3, cAMP-dependent transcription factor ATF-3
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: human (Recombinant)
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 13A5.1, monoclonal
• 交差性: mouse, human
• テクニック: western blot: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_001665
• UniProtアクセッション番号: P18847
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ATF3(467)

詳細

詳細

Cyclic AMP-dependent transcription factor ATF-3 (UniProt P18847; also known as Activating transcription factor 3, cAMP-dependent transcription factor ATF-3) is encoded by the ATF3 gene (Gene ID 467) in human. ATF-3 belongs to the ATF/cAMP-responsive element-binding protein family of basic leucine zipper-type transcription factors. ATF-3 is markedly induced and functions as either a transcriptional activator or repressor in response to LPS, cytokines, hormones, DNA damage, and ER stress in various cell types. ATF3 plays key roles in atherosclerosis and hyperlipidemia, and is reported to negatively regulate the differentiation of adipocyte, chondrocyte, and osteoblast. ATF-3 dysfunction is closely related to various inflammatory diseases and cancer.

特異性

Expected to react with spliced isoforms 1 and 5 (UniProt P18847-1 and P18847-5). Reactivity toward spliced isoforms 2, 3, and 4 (UniProt P18847-2 through P18847-4) of human ATF-3 has not been determined.

免疫原

GST-tagged recombinant human ATF-3 fragment.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
神経変性疾患

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of RAW264.7 cell lysate.

品質

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of THP-1 cell lysate.

ターゲットの説明

~19 kDa observed.

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable