MABC598

Anti-PACS2 Antibody, clone 9F12.2

clone 9F12.2, from mouse

• 別名: Phosphofurin acidic cluster sorting protein 2, PACS1-like protein, PACS2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 9F12.2, monoclonal
• 化学種の反応性: mouse, rat
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001094383
• UniProtアクセッション番号: Q86VP3
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Pacs2(217893)

詳細

詳細

Phosphofurin acidic cluster sorting protein 2 (PACS2), also known as PACS-2, PACS1-like protein, and encoded by the gene name PACS2/ KIAA0602/ PACS1L, is a amember of the PACS family. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally, PACS2 translocates BIB to mitochondria in response to apoptic inducers, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome C, and the activation of caspase-3 thereby causing cell death. Recent studies have indicated that PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. PACS2 interacts with BID, PKD2, and HIV-1 Nef.

免疫原

GST-tagged recombinant protein corresponding to Human PACS2.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

This Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.

Western Blotting Analysis: A 1:500 dilution from a representative lot detected PACS2 in 10 µg of mouse hypothalamus tissue.

品質

Evaluated by Western Blotting in rat hippocampus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PACS2 in 10 µg of rat hippocampus tissue lysate.

ターゲットの説明

~100 kDa observed

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1