MABE1020

Anti-Acetyl Lysine, Pan, clone RM101 Antibody

clone RM101, from rabbit, purified by affinity chromatography

• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: RM101, monoclonal
• application: DB; ICC; IP; WB
• 化学種の反応性: human
• テクニック: dot blot: suitable; immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: RM101, monoclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: all (based on 100% sequence homology)
• テクニック: dot blot: suitable; immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• アイソタイプ: IgG
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

DNA is tightly packed in the nucleus into nucleosomes, generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

免疫原

Acetyl lysine-BSA corresponding to all species.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
核受容体

Anti-Acetyl Lysine, Pan, clone RM101 is an antibody against Acetyl Lysine, Pan for use in WB, Dot Blot, ICC, IP.

Immunocytochemistry Analysis: A representative lot detected Acetyl Lysine, Pan in A431 cells.
Dot Blot Analysis: A 1:2,000 dilution from a representative lot detected Acetyl Lysine, Pan in an Absurance Histone H3 Antibody Specificity Array (Cat. No. 16-667) and an Absurance Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665).
Immunoprecipitation Analysis: A 1:500 dilution from a representative lot immunoprecipitated Acetyl Lysine, Pan in A431 cell lysate.

品質

Evaluated by Western Blotting in Trichostatin A (TSA) treated HeLa cell lysate.

Western Blotting Analysis: A 1:2,000 of this antibody detected Acetyl Lysine, Pan in Trichostatin A (TSA) treated HeLa cell lysate.

物理的形状

Protein A purified

Purified rabbit monoclonal IgG in buffer containing PBS with 1% BSA and 0.09% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable