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由来生物
mouse
品質水準
抗体製品の状態
purified antibody
抗体製品タイプ
primary antibodies
クローン
1C7, monoclonal
化学種の反応性
human
テクニック
flow cytometry: suitable
inhibition assay: suitable
アイソタイプ
IgG1κ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... LIFR(3977)
詳細
The LIF receptor is critical in modern mouse stem cell maintenance as the receptor for LIF, the embryonic stem cell (ESC) growth factor that maintains pluripotency and self renewal in mouse ES cells, however physiologically, the importance of LIF-R in real mouse development has been less clear. LIF receptor does play a signaling role and when cleaved its extracellular portion can act as a decoy receptor and block exogenous LIF from performing its function on ES cells. LIF receptor is expressed in multiple tissues in the mouse during development from the liver to the lung and brain. LIF receptor also is important in immune responses and in the stimulation of the interferon response to viral infection. Also LIF receptor has recently been identified as a metastasis suppressor that functions through the Hippo-YAP pathway in humans.
免疫原
Recombinant protein corresponding to mouse LIF Receptor.
アプリケーション
Research Category
幹細胞研究
幹細胞研究
Research Sub Category
細胞周期、DNA複製及び修復
細胞周期、DNA複製及び修復
Anti-LIF Receptor, clone 1C7 (Azide Free) is an antibody against LIF Receptor for use in FC, Inhibition.
Inhibition Assay Analysis: A representative lot detected LIF Receptor in LIF binding to JAR cells (Blanchard, F., et al. (1997) International Immunology. 9(12):1775-1784).
Inhibition Assay Analysis: A representative lot detected LIF Receptor in IL3 proliferative response in Ba/F3 cells (Pitard, V., et al. (1997) Journal of Immunological Methods. 205:177-190).
Inhibition Assay Analysis: A representative lot detected LIF Receptor in IL3 proliferative response in Ba/F3 cells (Pitard, V., et al. (1997) Journal of Immunological Methods. 205:177-190).
品質
Evaluated by Flow Cytometry in CHO D1IgD2-mycDAF cells .
Flow Cytometry Analysis: 1.0 µg of this antibody detected LIF Receptor in CHO D1IgD2-mycDAF.
Flow Cytometry Analysis: 1.0 µg of this antibody detected LIF Receptor in CHO D1IgD2-mycDAF.
ターゲットの説明
123 kDa calculated
物理的形状
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
その他情報
Concentration: Please refer to lot specific datasheet.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MABD150:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.
Voisin, MB; Bitard, J; Daburon, S; Moreau, JF; Taupin, JL
The Journal of Biological Chemistry null
Epitope-function relationships of human leukemia inhibitory factor receptors using a novel set of anti-gp190 mAB.
Blanchard, F; Pitard, V; Taupin, JL; Raher, S; Hallet, MM; Moreau, JF; Godard, A; Jacques, Y
International Immunology null
V Pitard et al.
Journal of immunological methods, 205(2), 177-190 (1997-07-14)
Leukemia inhibitory factor (LIF), oncostatin-M (OSM), ciliary neurotrophic factor (CNTF) and cardiotrophin-1 (CT1) act through transmembrane receptors which share the gp190 glycoprotein chain. The understanding of its involvement in the biology of these cytokines is of importance since these systems
J L Taupin et al.
The Journal of biological chemistry, 276(51), 47975-47981 (2001-10-19)
The receptor for the cytokine leukemia inhibitory factor (LIF) associates the low affinity binding component gp190 and the high affinity converter gp130, both of which are members of the family of hematopoietic receptors characterized by the cytokine receptor homology (CRH)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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