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Merck
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主要文書

MAB390-100UG

Sigma-Aldrich

Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

clone 192, Chemicon®, from mouse

別名:

p75 Low Affinity Neurotrophin Receptor, NGFR

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About This Item

UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
結合体:
saporin
application:
immunolesioning
クローン:
192, monoclonal
化学種の反応性:
rat
citations:
18
テクニック:
immunolesioning: suitable

由来生物

mouse

品質水準

結合体

saporin

抗体製品タイプ

primary antibodies

クローン

192, monoclonal

化学種の反応性

rat

以下との反応禁止

mouse, human

メーカー/製品名

Chemicon®

テクニック

immunolesioning: suitable

アイソタイプ

IgG1

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

dry ice

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... NGFR(4804)

特異性

Rat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP

アプリケーション

Research Category
ニューロサイエンス
Research Sub Category
神経変性疾患

神経化学・ニューロトロフィン
Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is an antibody against p75 Low Affinity Nerve Growth Factor Receptor for use in 0.
Immunotoxin (see "Protocols" for Technical Notes)

物理的形状

Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco′s PBS with no preservative.

保管および安定性

Centrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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試験成績書(COA)

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Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory.
McMahan, R W, et al.
Hippocampus, 7, 130-136 (1997)
M M Nicolle et al.
Neuroscience, 77(3), 649-659 (1997-04-01)
Lesion models in the rat were used to examine the effects of removing innervation of the hippocampal formation on glutamate receptor binding in that system. Bilateral aspiration of the entorhinal cortex was used to remove the cortical innervation of the
Toxin-induced death of neurotrophin-sensitive neurons.
R G Wiley
Methods in molecular biology (Clifton, N.J.), 169, 217-222 (2001-01-06)
Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor.
Heckers, S, et al.
The Journal of Neuroscience, 14, 1271-1289 (1994)
J J Waite et al.
Neuroscience, 65(2), 463-476 (1995-03-01)
Immunolesions of the cholinergic basal forebrain were produced in rats using various intraventricular doses of the immunotoxin 192 immunoglobulin G-saporin: 0.34, 1.34, 2.0, 2.7 and 4.0 micrograms/rat. A battery of behavioral tests, chosen on the basis of reported sensitivity to

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