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由来生物
rabbit
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
rat
包装
antibody small pack of 25 μL
テクニック
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
アイソタイプ
IgG
NCBIアクセッション番号
UniProtアクセッション番号
ターゲットの翻訳後修飾
unmodified
遺伝子情報
rat ... Gpc1(58920)
詳細
Glypican-1 (UniProt: P35053; also known as GPC1, HSPG M12) is encoded by the Gpc1 gene (GeneID: 58920) in rat. Glypican-1 is attaches to the plasma membrane via glycosylphosphatidylinositol (GPI) anchors. It is a cell surface proteoglycan that bears heparan sulfate and may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Glypican-1 is required for proper skeletal muscle differentiation. It sequesters FGF2 in lipid rafts and blocks its binding to FGF receptors. Glypican-1 is specifically enriched on cancer-cell-derived exosomes and levels of glypican-1 positive exosomes correlate with tumor burden and the survival of pre- and post-surgical patients. Glypican-1 expression, both mRNA and protein, is upregulated in human pancreatic cancers cells and adjacent fibroblasts. (Ref.: Melo, SA et al. 2015. Nature. 523(7559):177-82; Kleeff, J et al. 1998. J. Clin. Invest. 102(9), 1662 1673).
特異性
This rabbit polyclonal antibody detects Glypican-1 in Rat C6 glioma cells.
免疫原
Epitope: unknown
GST-tagged recombinant fragment corresponding to the first 423 amino acids of rat Glypican-1.
アプリケーション
Research Category
細胞骨格
細胞骨格
Anti-Glypican-1 Antibody, Cat. No. ABT1385 is a rabbit polyclonal antibody that detects Glypican-1 and is tested for use in Immunocytochemistry, Immunohistochemistry, and Western Blotting.
Western Blotting Analysis: A representative lot detected Glypican-1 in rat brain homogenates and rat C6 glioma cells treated with heparitinase (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunocytochemistry Analysis: A representative lot detected Glypican-1 in rat C6 glioma cells (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunohistochemistry Analysis: A representative lot detected Glypican-1 in rat spinal cord and brain (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunocytochemistry Analysis: A representative lot detected Glypican-1 in rat C6 glioma cells (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunohistochemistry Analysis: A representative lot detected Glypican-1 in rat spinal cord and brain (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
品質
Evaluated by Immunocytochemistry in Rat C6 glioma cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Glypican-1 in Rat C6 glioma cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Glypican-1 in Rat C6 glioma cells.
ターゲットの説明
61.73 kDa calculated.
物理的形状
Unpurified
Rabbit polyclonal antiserum with 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
その他情報
Concentration: Please refer to lot specific datasheet.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ABT1385:
ABT1385-25UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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