AB8230

Anti-Syndecan-1 Antibody

serum, from rabbit

• 別名: CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor ; ; receptor, syndecan 1, syndecan proteoglycan 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: serum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: mouse, human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NM_001006946.1
• UniProtアクセッション番号: P18827
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SDC1(6382)

詳細

詳細

Syndecan-1, also known as CD138, is a transmembrane (Type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization. Bearing properties of both heparan sulfate and chondroitin sulfate, Syndecan-1 functions as a cell surface proteoglycan membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.

特異性

Cat. No. AB8230 recognizes mouse Syndecan-1.

Predicted to cross react with human, based on 100% sequence homology.

Reactivity with other species has not been tested.

免疫原

His-tagged, full-length human recombinant Syndecan-1 protein.

アプリケーション

Research Category
細胞骨格

Research Sub Category
ECMタンパク質

Anti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB.

品質

Evaluated on a representative lot by Western blot on mouse liver lysate using 1:1000 dilution of Anti-Syndecan-1.

ターゲットの説明

The expected molecular weight of monomeric Syndecan-1 is ~32 kDa; however, the core protein often migrates as an SDS-stable dimer with an approximate M.W. of 77 kDa Additionally, a high M.W. form of the protein may often be seen between 500-1000 kDa, likely the mature form of Syndecan-1, with all of its heparan and chondroitin sulfate additions. In whole tissues, this mature form often binds tightly to ECM molecules and may require solublization by urea extraction for additional SDS-PAGE analysis (Wilsie, 2006). Triton X-100 or similar mild detergents are sufficient to release the immature precursor forms of Syndecan-1.

物理的形状

Rabbit serum containing 0.05% NaN3.

保管および安定性

Maintain at -20°C for up to 1 year from date of receipt.

アナリシスノート

Control
Mouse liver lysate

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1