ABS94

Anti-MLK1 Antibody

from rabbit, purified by affinity chromatography

• 別名: Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 交差性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• テクニック: immunohistochemistry: suitable (paraffin)
• NCBIアクセッション番号: NP_149132
• UniProtアクセッション番号: P80192
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MAP3K9(4293)

詳細

詳細

MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.

免疫原

KLH-conjugated linear peptide corresponding to human MLK1.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
キナーゼ及びホスファターゼ

Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).

品質

Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.

ターゲットの説明

121 kDa (isoform 1), 123 kDa (isoform 2) calculated

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Colorectal adenocarcinoma tissue

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids