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Merck

AB3841

Sigma-Aldrich

Anti-Connexin 43 Antibody, phospho-specific (Ser368)

Chemicon®, from rabbit

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About This Item

UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41

由来生物

rabbit

品質水準

抗体製品の状態

affinity purified immunoglobulin

抗体製品タイプ

primary antibodies

クローン

polyclonal

精製方法

affinity chromatography

化学種の反応性

hamster, mouse, rat, monkey, human

メーカー/製品名

Chemicon®

テクニック

western blot: suitable

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

dry ice

ターゲットの翻訳後修飾

phosphorylation (pSer368)

遺伝子情報

human ... GJA1(2697)

特異性

Recognizes Ser368 phosphorylated Connexin 43. Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap-junction communication is important in development and regulation of cell growth.

免疫原

Epitope: phospho-specific (Ser368)
KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser368 of human Connexin 43.

アプリケーション

Research Category
細胞骨格
Research Sub Category
接着分子(CAM)
This Anti-Connexin 43 Antibody, phospho-specific (Ser368) is validated for use in WB for the detection of Connexin 43.
Western blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

Optimal working dilutions must be determined by the end user.

物理的形状

Protein A and peptide affinity purified immunoglobulin. Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol.

保管および安定性

Maintain at -20ºC for 12 months after date of receipt. Do not aliquot.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 2


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

AB3841:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Mechanisms of unpinning and termination of ventricular tachycardia.
Ripplinger, CM; Krinsky, VI; Nikolski, VP; Efimov, IR
American Journal of Physiology. Heart and Circulatory Physiology null
Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43.
Azarashvili, T; Baburina, Y; Grachev, D; Krestinina, O; Evtodienko, Y; Stricker, R; Reiser, G
American Journal of Physiology. Cell Physiology null
David Johansen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 28(1), 103-114 (2011-08-26)
Gap junction intercellular communication (GJIC) and hemichannel permeability may have important roles during an ischemic insult. Our aim was to evaluate the effect of ischemia on gap junction channels and hemichannels. We used neonatal rat heart myofibroblasts and simulated ischemia
Ronald Ng et al.
JCI insight, 5 (2019-06-14)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder with variable genetic etiologies. Here we focused on understanding the precise molecular pathology of a single clinical variant in DSP, the gene encoding desmoplakin. We initially identified a novel missense desmoplakin variant (p.R451G)
Florian Alonso et al.
Cardiovascular research, 87(1), 166-176 (2010-01-30)
Connexins (Cxs) play a role in the contractility of the aorta wall. We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent hypertension. We

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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