8.51029

N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms)

Novabiochem^®

• 別名: N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms), O-(N-Biotinyl-3-aminopropyl)-O′-(N-glutaryl-3-aminopropyl)-diethyleneglycol · DIPEA
• 実験式（ヒル表記法）: C₂₅H₄₄N₄O₈S · xC₈H₁₉N
• CAS番号: 1205744-09-7
• 分子量: 560.70
• MDL番号: MFCD08458689
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• アッセイ: ≥95.0% (HPLC); ≥98% (TLC)
• フォーム: powder
• 反応適合性: reaction type: Biotinylations
• メーカー／製品名: Novabiochem^®
• mp: 131-136 °C
• アプリケーション: peptide synthesis
• 保管温度: 2-8°C
• SMILES記法: S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCOCCOCCOC(=O)O.N(C(C)C)(C(C)C)CC
• InChI: 1S/C17H29N3O7S.C8H19N/c21-14(18-5-6-25-7-8-26-9-10-27-17(23)24)4-2-1-3-13-15-12(11-28-13)19-16(22)20-15;1-6-9(7(2)3)8(4)5/h12-13,15H,1-11H2,(H,18,21)(H,23,24)(H2,19,20,22);7-8H,6H2,1-5H3/t12-,13-,15-;/m0./s1
• InChI Key: YOALVTBRBBZXGM-HZPCBCDKSA-N

詳細

詳細

The use of this novel biotin derivative incorporates a hydrophilic 20 atom PEG spacer between the peptide and biotin. This not only greatly improves the solubility of the resultant peptide, but reduces steric hindrance between the peptide and biotin, leading to better avidin binding and higher biological activity. The biotin-PEG derivative can be easily incorporated using any standard coupling method as the final step in SPPS, immediately prior to cleavage of the peptide from the resin.

Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis

関連事項

Replaces: 01-63-0133

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (50 mg in 1 ml NMP): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable