681636-M

W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

• 別名: W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
• 実験式（ヒル表記法）: C₁₄H₁₇ClN₂O₂S · xHCl
• CAS番号: 88519-57-7
• 分子量: 312.81 (free base basis)
• MDL番号: MFCD00058030
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: water: 35 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
• InChI Key: QKAALLVQBOLELJ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM) and myosin light chain kinase (IC₅₀ = 58 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

生物化学的／生理学的作用

Target IC₅₀: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

警告

Toxicity: Standard Handling (A)

アナリシスノート

single spot by TLC

その他情報

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable