574775-M

Swainsonine, Swainsona canescens

Reversible active-site inhibitor of lysosomal α-mannosidase.

• 別名: Swainsonine, Swainsona canescens, (1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
• 実験式（ヒル表記法）: C₈H₁₅NO₃
• CAS番号: 72741-87-8
• 分子量: 173.21
• MDL番号: MFCD00017554
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: water: 1 mg/mL; DMSO: 5 mg/mL; chloroform: soluble
• 保管温度: 2-8°C
• InChI: 1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
• InChI Key: FXUAIOOAOAVCGD-WCTZXXKLSA-N

詳細

詳細

Reversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.

生物化学的／生理学的作用

Primary Target
Lysosomal α-mannosidase

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

その他情報

Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol.98, 135.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3