565610

SC-560

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM).

• 別名: SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
• 実験式（ヒル表記法）: C₁₈H₁₂F₃IN₂O
• CAS番号: 188817-13-2
• 分子量: 456.20
• MDL番号: MFCD02179214
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 200 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
• InChI Key: PQUGCKBLVKJMNT-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM). Inhibits COX-2 only at higher concentrations (IC₅₀ = 6.3 µM).

A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC₅₀ = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC₅₀ = 6.3 µM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 9 nM against COX-1

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable