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アッセイ
≥98% (HPLC)
品質水準
形状
solid
メーカー/製品名
Calbiochem®
保管条件
OK to freeze
desiccated (hygroscopic)
protect from light
色
white to pale yellow
溶解性
DMSO: 1.6 mg/mL
water: 50 mg/mL
保管温度
−20°C
詳細
A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.
A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
生物化学的/生理学的作用
Cell permeable: yes
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
物理的形状
Supplied as HCl salt.
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
その他情報
Wang, T., et al. 2015. J. Med. Chem.58, 3025.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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