528105

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

• 別名: Picrotoxin, Anamirta cocculin
• 実験式（ヒル表記法）: C₁₅H₁₈O₇ · C₁₅H₁₆O₆
• CAS番号: 124-87-8
• 分子量: 602.58
• MDL番号: MFCD00074824
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (mixture of Picrotoxin and picrotin, HPLC)
• 形状: crystals; powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white to light yellow
• 溶解性: aqueous base: 3 mg/mL; ethanol: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
• InChI Key: VJKUPQSHOVKBCO-ZTYBEOBUSA-N

詳細

詳細

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^- channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

警告

Toxicity: Highly Toxic (H)

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable