525145

sPLA₂-IIA Inhibitor I

The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• 別名: sPLA₂-IIA Inhibitor I, c(2NapA)LS(2NapA)R, TFA
• 実験式（ヒル表記法）: C₄₁H₅₀N₈O₆ · xC₂HF₃O₂
• 分子量: 750.89 (free base basis)
• UNSPSCコード: 41106300
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA₂-IIA (human type IIA secreted phospholipase A₂; IC₅₀ = 12.8 μM). Shown to effectively block sPLA₂-IIA-induced PGE₂ production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA₂-IB, Naja naja sPLA₂-IB, or Crotalus durissus sPLA₂-IIA even at 10 μM concentration.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
sPLA2-IIA (human type IIA secreted phospholipase A2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA

その他情報

Church, W.B., et al. 2001. J. Biol. Chem.276, 33156.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable