506274

PACOCF₃

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

• 別名: PACOCF₃, Palmitoyl Trifluoromethyl Ketone
• 実験式（ヒル表記法）: C₁₇H₃₁F₃O
• CAS番号: 141022-99-3
• 分子量: 308.42
• MDL番号: MFCD00797669
• UNSPSCコード: 12352211
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (TLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: FC(F)(F)C(=O)CCCCCCCCCCCCCCC
• InChI: 1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
• InChI Key: MAHYXYTYTLCTQD-UHFFFAOYSA-N

詳細

詳細

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent PLA₂ at much higher concentrations (IC₅₀ = 45 µM).

A novel Ca²⁺-independent phospholipase A₂ inhibitor (IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent phospholipase A₂ at higher concentrations (IC₅₀ = 45 µM)

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.

Supplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.

その他情報

Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3