5.06239

Bupropion Hydrochloride

• 別名: Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
• 実験式（ヒル表記法）: C₁₃H₁₈ClNO · xHCl
• CAS番号: 31677-93-7
• 分子量: 239.74 (free base basis)
• MDL番号: MFCD00055209
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 1.4 μM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: soluble
• 保管温度: 2-8°C
• SMILES記法: Clc1cc(ccc1)C(=O)C(NC(C)(C)C)C.Cl
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• InChI Key: HEYVINCGKDONRU-UHFFFAOYSA-N

詳細

詳細

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀ = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

生物化学的／生理学的作用

Primary Target
DAT/NET

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable