5.05026

DNQX Disodium Salt

• 別名: DNQX Disodium Salt, AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX
• 実験式（ヒル表記法）: C₈H₂N₄Na₂O₆
• CAS番号: 2379-57-9
• 分子量: 296.10
• MDL番号: MFCD00069257
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: dark brown
• 溶解性: H₂O: 100 mM
• 保管温度: 2-8°C
• SMILES記法: [N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1[N+](=O)[O-])=O)=O
• InChI: 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• InChI Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N

詳細

詳細

A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC₅₀ = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.

生物化学的／生理学的作用

Primary Target
AMPA

Secondary Target
GluK2

Target IC₅₀: 0.19 to 1.66 uM

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable