483125-M

N^G-Nitro-L-arginine Methyl Ester, Hydrochloride

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

• 別名: N^G-Nitro-L-arginine Methyl Ester, Hydrochloride, N ^ω-NO₂-L-Arg-OMe, N ^G-NO₂-L-Arg-OMe, L-NAME, HCl, N^ω-NO₂-L-Arg-OMe, N^G-NO₂-L-Arg-OMe, L-NAME, HCl
• 実験式（ヒル表記法）: C₇H₁₅N₅O₄ · xHCl
• CAS番号: 51298-62-5
• 分子量: 233.23 (free base basis)
• MDL番号: MFCD00039052
• UNSPSCコード: 12352209
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white to off-white
• 溶解性: water: 50 mg/mL
• 保管温度: −20°C
• InChI: 1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
• InChI Key: QBNXAGZYLSRPJK-JEDNCBNOSA-N

詳細

詳細

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

生物化学的／生理学的作用

Primary Target
eNOS

Target IC₅₀: 500 nM against eNOS

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

その他情報

Baylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA88, 6368.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Moore, P.K., et al. 1990. Br. J. Pharmacol.99, 408.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable