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品質水準
アッセイ
≥99% (HPLC)
フォーム
solid
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
色
white
溶解性
DMSO: 20 mg/mL
ethanol: 3 mg/mL
輸送温度
ambient
保管温度
−20°C
InChI
1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChI Key
PZRHRDRVRGEVNW-UHFFFAOYSA-N
詳細
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
生物化学的／生理学的作用
Cell permeable: yes
Primary Target
PDE 3
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against PDE III
警告
Toxicity: Toxic (F)
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
その他情報
Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.
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法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Oral
保管分類コード
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
毒物及び劇物取締法
劇物
Jan Code
475840-MG:
475840-10MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
D Wilhelm et al.
Journal of cardiovascular pharmacology, 20(5), 705-714 (1992-01-01)
The cardiac in vitro effects of R 80122, a novel phosphodiesterase (PDE) inhibitor, were investigated and compared with those of the reference compound milrinone and of the calcium-sensitizer adibendan. In guinea pig left atria, both milrinone and R 80122 increased
S A Harrison et al.
Molecular pharmacology, 29(5), 506-514 (1986-05-01)
We have identified and highly purified a "low Km" cAMP phosphodiesterase from bovine cardiac muscle. This phosphodiesterase was inhibited by low concentrations of cGMP and has, therefore, been temporarily designated as cGMP-inhibited phosphodiesterase. After a 16,000-fold increase in specific activity
J M Bailey et al.
Anesthesiology, 81(3), 616-622 (1994-09-01)
Milrinone is a phosphodiesterase inhibitor with positive inotropic and vasodilator effects that are useful in the treatment of ventricular dysfunction after cardiac surgery. However, the pharmacokinetics of the drug have been investigated only in healthy volunteers and in patients with
S H Lindgren et al.
Acta physiologica Scandinavica, 140(2), 209-219 (1990-10-01)
The inhibitors of the cGMP-inhibited, low-Km cAMP phosphodiesterase--milrinone and OPC 3911--and an inhibitor of a non-cGMP-inhibited low-Km cAMP phosphodiesterase--rolipram--were used to evaluate the functional importance of the two cAMP phosphodiesterase activities in vascular smooth muscle and in platelets. Vinpocetine, an
Luping Yu et al.
Development (Cambridge, England), 148(2) (2020-12-16)
Alternative splicing (AS) contributes to gene diversification, but the AS program during germline development remains largely undefined. Here, we interrupted pre-mRNA splicing events controlled by epithelial splicing regulatory protein 1 (ESRP1) and found that it induced female infertility in mice.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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