444274

MMP-2/MMP-9 Inhibitor IV

The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: MMP-2/MMP-9 Inhibitor IV, SB-3CT
• 実験式（ヒル表記法）: C₁₅H₁₄O₃S₂
• CAS番号: 292605-14-2
• 分子量: 306.40
• MDL番号: MFCD09836266
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• 有効性: 13.9 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
• InChI Key: LSONWRHLFZYHIN-UHFFFAOYSA-N

詳細

詳細

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM) and MMP-9 (K_i = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (K_i = 206 µM) MMP-3 (K_i = 15 µM), or MMP-7 (K_i = 96 µM).

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM), and MMP-9 (K_i = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Krüger, A., et al. 2005. Cancer Res.65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799.

法的情報

Sold under license of U.S. Patent 6,703,415.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable