444249

MMP-2/MMP-9 Inhibitor II

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: MMP-2/MMP-9 Inhibitor II, (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
• 実験式（ヒル表記法）: C₂₁H₂₀N₂O₄S
• CAS番号: 193807-60-2
• 分子量: 396.46
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white
• 溶解性: DMSO: 100 mg/mL; methanol: 25 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A potent inhibitor of MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

A potent inhibitor of type IV collagenases, MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
MMP-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable