420134

JNK Inhibitor VII, TAT-TI-JIP_153-163, Cell-Permeable

The JNK Inhibitor VII, TAT-TI-JIP_153-163, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: JNK Inhibitor VII, TAT-TI-JIP_153-163, Cell-Permeable, H₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
• 実験式（ヒル表記法）: C₁₂₅H₂₂₀N₅₂O₂₇
• 分子量: 2883.42
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 溶解性: water: 1 mg/mL; DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

The non-permeant JNK inhibitor peptide TI-JIP_153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
JNK

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Guan, Q.H., et al. 2006. Neuroscience, 139, 609.
Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable