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Merck

407950

Sigma-Aldrich

Ionomycin free acid

from Streptomyces conglobatus, ≥90% (HPLC), waxy solid, Ca2+ mobile ion carrier, Calbiochem®

別名:

Ionomycin, Free Acid, Streptomyces conglobatus

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About This Item

実験式(ヒル表記法):
C41H72O9
CAS番号:
分子量:
709.00
MDL番号:
UNSPSCコード:
12352106
NACRES:
NA.77

product name

Ionomycin, Free Acid, Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.

品質水準

アッセイ

≥90% (HPLC)

形状

waxy solid

メーカー/製品名

Calbiochem®

保管条件

OK to freeze
protect from light

溶解性

DMSO: 10 mg/mL
methanol: 10 mg/mL

輸送温度

ambient

保管温度

2-8°C

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1

InChI Key

PGHMRUGBZOYCAA-OJFQOPKISA-N

詳細

Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.

生物化学的/生理学的作用

Cell permeable: no
Primary Target
Mobile ion carrier for Ca2+
Product does not compete with ATP.
Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.

その他情報

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem.253, 5892.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 3


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

407950-1MG:
407950-5MG:
407950-VMG:
407950-10MG:


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