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アッセイ
≥95% (SDS-PAGE)
品質水準
形状
liquid
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
溶解性
sterile distilled water: soluble
輸送温度
ambient
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
詳細
Immunoglobulin G (IgG) is the most crucial glycoprotein antibody. It has the longest serum half-life compared to other immunoglobulins. IgG is present in human serum and also identified in the bloodstream. It contains four polypeptide chains, wherein the light and heavy chains are linked by disulfide bonds.
アプリケーション
Human IgG, Fab Fragment, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).
生物化学的／生理学的作用
Immunoglobulin G (IgG) initiates the classical pathway of the complement system and eliminates virus particles and toxins. It controls antibody-dependent cell-mediated cytotoxicity (ADCC) and might be correlated to allergy. Digestion of IgG by papain generates fragment antigen-binding (Fab) whereas pepsin digestion of IgG releases crystallizable (Fc) fragment and a single dimeric F(ab)2. Maternal IgG is transferred to the fetus via the placenta and is crucial for the immune defense of the neonate against infections. IgG levels in severe acute respiratory syndrome coronavirus (SARS-CoV)2 infected patients may be useful to understand the severity and prognosis of coronavirus disease 2019 (COVID-19).
警告
Toxicity: Standard Handling (A)
物理的形状
In 150 mM NaCl, 20 mM sodium phosphate buffer, 0.05% NaN₃, pH 7.4.
調製ノート
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies of HIV and HCV.
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
401116-2MG:
401116-MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
S G Johansson et al.
Allergy, 56(9), 813-824 (2001-09-12)
This report has been prepared by an EAACI task force representing the five EAACI Sections and the EAACI Executive Committee composed of specialists that reflect the broad opinion on allergy expressed by various clinical and basic specialties dealing with allergy.
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Hongyan Hou et al.
Clinical & translational immunology, 9(5), e01136-e01136 (2020-05-10)
This study aimed to determine the IgM and IgG responses against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with varying illness severities. IgM and IgG antibody levels were assessed via chemiluminescence immunoassay in 338 COVID-19
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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