400084

HIF Prolyl Hydroxylase Inhibitor

• 別名: HIF Prolyl Hydroxylase Inhibitor
• 実験式（ヒル表記法）: C₂₁H₁₆ClN₃O
• CAS番号: 385786-48-1
• 分子量: 361.82
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: tan
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC₅₀ = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC₅₀ = 0.25 µM in an oxidative stress model using cortical neurons.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable