382149

Histone Deacetylase Inhibitor III

The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: Histone Deacetylase Inhibitor III, M344, 4-Dimethylamino- N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide, M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
• 実験式（ヒル表記法）: C₁₆H₂₅N₃O₃
• CAS番号: 251456-60-7
• 分子量: 307.39
• MDL番号: MFCD03453554
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
• InChI Key: MXWDSZWTBOCWBK-UHFFFAOYSA-N

詳細

詳細

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Rat liver HDAC

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 40 nM for rat liver HDAC

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753.
Jung, M., et al. 1999. J. Med. Chem.42, 4669.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable