365251

Gö 6983

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.

• 別名: Gö 6983, 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
• 実験式（ヒル表記法）: C₂₆H₂₆N₄O₃
• CAS番号: 133053-19-7
• 分子量: 442.51
• MDL番号: MFCD04040031
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange-red
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
• InChI Key: LLJJDLHGZUOMQP-UHFFFAOYSA-N

詳細

詳細

A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; and 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PKCα and PKCβ

Product competes with ATP.

Reversible: yes

Target IC₅₀: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ

警告

Toxicity: Standard Handling (A)

その他情報

Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3