220551

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

• 別名: Chloramphenicol
• 実験式（ヒル表記法）: C₁₁H₁₂Cl₂N₂O₅
• CAS番号: 56-75-7
• 分子量: 323.13
• MDL番号: MFCD00078159
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥97% (by Assay)
• 形状: crystalline powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: gray to off-white
• 溶解性: water: 2.5 mg/mL; methanol: 35 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
• InChI Key: WIIZWVCIJKGZOK-UHFFFAOYSA-N

詳細

詳細

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

生物化学的／生理学的作用

Potency: ≥970 µg/mg

Primary Target
trasnslation of RNA

その他情報

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS05
• シグナルワード: Danger
• 危険有害性情報: H318,H351,H361fd
• 注意書き: P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501
• 危険有害性の分類: Carc. 2 - Eye Dam. 1 - Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3