215921

Chlorpromazine, Hydrochloride

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

• 別名: Chlorpromazine, Hydrochloride
• 実験式（ヒル表記法）: C₁₇H₁₉ClN₂S · xHCl
• CAS番号: 69-09-0
• 分子量: 318.86 (free base basis)
• MDL番号: MFCD00012654
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: off-white
• 溶解性: methanol: 10 mg/mL; water: 50 mg/mL
• 微量陰イオン: sulfate (SO₄^2-): ≤0.05%
• 微量陽イオン: Fe: ≤0.001%; heavy metals: ≤0.002%
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI Key: FBSMERQALIEGJT-UHFFFAOYSA-N

詳細

詳細

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

生物化学的／生理学的作用

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

警告

Toxicity: Toxic (F)

再構成

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

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Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H330
• 注意書き: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• 危険有害性の分類: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable